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How supraphysiological preconditioning™ works

Using the BLOOM⁴³ device delivers safe and effective supraphysiological preconditioning™ to the breast skin on the night before surgery.


By gently warming the skin, the device causes the release of a special group of naturally occurring proteins within the body’s cells called ‘Heat Shock Proteins’, or HSPs. These protective proteins help our cells maintain their normal function. In particular, HSP-32 triggers the natural release of carbon monoxide into the surrounding tissue.


Carbon monoxide is a highly effective vasodilator, making blood vessels open up and thereby increasing blood flow to the area. Better blood flow means better healing.